Sofia Rocha Pauleta

Principal Investigator
Secção de Bioquímica e Biofísica
(+351) 212948300
(+351) 212948550

Research Interests

1-Orange Protein Complex - Molecular system involved in cell division of strict anaerobic bacteria. Target to control biocorrosion (Post-doc: B. Maiti, O. Mestre, BI: R. Nunes, MSc Student: A. Neca). PI Funded Project
2-Pathogen Control - bacterial systems involved in detoxification of reactive oxygen and nitrogen species produced by immune system. (PhD student C. Nóbrega, BSc student: D. Chainho)
3-Nitrous oxide reductase - mechanistic and structural studies. Reducing the potent greenhouse gas-nitrous oxide. Determination of environmental conditions that influence the activity of this enzyme (Post-doc S. Ramos, PhD student C. Carreira)
4-Copper and other metals tolerance in Bacteria related with pathogenesis. (protein immobilization for biosensing and bioremediation)
5-Hyperpolarization-activated cyclic nucleotide-gated channels - solution structure of CNBD domain in free and cAMP bound form. Interaction with TRIP8bmini (Collaborative project. Anna Moroni,Italy) 

Main Publications

Total Publications: 39
ResearchID: F-3619-2011
Scopus Author ID: 6507722953
ORCID: orcid.org/0000-0002-2149-9416

11. A. Saponaro, Sofia R. Pauleta, F. Cantini, M. Matzapetakis, C. Hammann, C. Donadoni, L. Hu, G. Thiel, L. Banci, B. Santoro, A. Moroni. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. 2014. PNAS 111(40):14577-82. DOI: 10.1073/pnas.1410389111. Epub Sept 2.

10. M.S.P. Carepo, Sofia R. Pauleta*,**, A.G. Wedd, J.J.G. Moura, I. Moura. Mo-Cu metal cluster formation and binding in an Orange Protein isolated from Desulfovibrio gigas. 2014. J. Biol. Inorg. Chem. 19(4-5):605-14. DOI: 10.1007/s00775-014-1107-8.

9. E.M. Johnston, S. Dell'acqua, S. Ramos, Sofia R. Pauleta, I. Moura, E.I. Solomon. Determination of the active form of the tetranuclear copper sulfur cluster in nitrous oxide reductase. 2014. J. Am. Chem. Soc. 136(2):614-7. DOI: 10.1021/ja411500p.

8. Book Chapter: R. Grazina, Sofia R. Pauleta*, J.J.G. Moura, I. Moura. 3.06 - Iron-sulfur centers: new roles for ancient metal sites. In "Comprehensive Inorganic Chemistry II". Vol. 3: Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine. Ed. Vincent Pecoraro. 2013. page 103-48. Elsevier. ISBN: 9780080977744. DOI: 10.1016/B978-0-08-097774-4.00308-9.

7. Book Chapter: S. Dell’Acqua, Sofia R. Pauleta**,*, I. Moura, J.J.G. Moura. Nitrous Oxide Reductase. In "Encyclopedia of Metalloproteins - Copper". 2013. Eds. R.H. Kretsinger, V. N. Uversky, E.A. Permyakov. Springer. ISBN: 978-1-4614-1532-9.

6. R. M. Almeida, P. Turano, J.J.G. Moura, Sofia R. Pauleta*. Superoxide Reductase: different interaction modes with its two redox partners. 2013. ChemBioChem. 14(14):1858-66. DOI: 10.1002/cbic.201300196.
Chosen for Inside Cover.

5. A. Thapper, A. C. Rizzi, C.D. Brondino, A.G. Wedd, R.J. Pais, B.K. Maiti, I. Moura, Sofia R. Pauleta*, J.J.G. Moura. Copper-substituted forms of the wild type and C42A variant of rubredoxin. 2013. J. Inorg. Biochemistry. 127:232-7. Epub 13 June. DOI: 10.1016/j.jinorgbio.2013.06.003.

4. C. S. Nóbrega, M. Matzapetakis, Sofia R. Pauleta*. 1H, 13C and 15N resonance assignment of the soluble form of the Lipid-modified Azurin from Neisseria gonorrhoeae. 2013. Biomolecular NMR assignments. 7(2):311-4. Epub 16th October 2012. DOI: 10.1007/s12104-012-9434-6.

3. Sofia R. Pauleta*, S. Dell’Acqua, I. Moura, Nitrous oxide reductase. Coord. Chem. Rev. 2013. 257:332–49. DOI: 10.1016/j.ccr.2012.05.026.

2. R.G. Hadt, X. Xie, Sofia R. Pauleta, I. Moura, E.I. Solomon. Analysis of resonance Raman data on the blue copper site in pseudoazurin: Excited state π and σ charge transfer distortions and their relation to ground state reorganization energy. J. Inorg. Biochem. 2012. 115:155-62. doi: 10.1016/j.jinorgbio.2012.03.006.

1. S. Dell'acqua, Sofia R. Pauleta*, J.J.G. Moura, I. Moura. Biochemical characterization of the purple form of Marinobacter hydrocarbonoclasticus nitrous oxide reductase. Phil. Trans. R. Soc. B. 2012. 367:1204-12.

Publication in National Journals

3. J.J.G. Moura, L.B. Maia, Sofia R. Pauleta, I. Moura. Química Bioinorgânica e Luz - Fotossíntese, Oxigénio e Água. 2015. Revista da Sociedade Portuguesa de Química. In Press.
2. L.B. Maia, Sofia R. Pauleta, J.J.G. Moura. Química de Coordenação e Biologia: controlo da actividade enzimática por alteração da coordenação de centros metálicos catalíticos. 2014. Revista da Sociedade Portuguesa de Química. 132(Jan-Mar):9-20.
1. Sofia R. Pauleta*, J.J.G. Moura. RMN Biomolecular – Desenvolvimentos recentes. Aplicações Modernas da RMN à Biologia. 2010. Revista da Sociedade Portuguesa de Química. 117(Abr-Jun):31-37.