Research interests are centred on: synthesis and thermodynamic behaviour of ionic liquids (ILs); liquid-liquid and vapour-liquid equilibrium; solubility mechanisms of ILs in water and other solvents; separation of azeotropic mixtures; purification and characterization of ILs; self-aggregation behaviour of ILs in water; drug delivery system based on biomolecules; extraction processes; modelling and simulation.
As principal investigator - "Fluorinated Ionic Liquids: New Engineering Solvents for Separation Processes" (Paulo Castro, Post-doc; Eduardo Sosa, PhD student; Andres E. Redondo, BI); "Design of Fluorinated Ionic Liquids as Novel Task-Specific Fluids" (Nicole Vieira, Post-doc; Margarida Ferreira, PhD; Ana Luísa Oliveira, MSc)
As coordinator - "KET4F-GAS Environmental Impact Mitigation of Fluorinates Gases using Key Enabling Technologies" (19 partners: 6 academic institutions, 1 public administration, 1 European platform, 1 Environmental Federation, 1 NGO, 1 Innovation Cluster, 2 private and public foundations and 6 industrial partners)
As team member - "Bridging Nature-Inspired Ionic Fluids and Microfluidic Aqueous Biphasic Systems for the Purification of Monoclonal Antibodies" (Joana Bastos, PhD; Sara Carvalho, PhD)
87 published articles, 3314 citations, h-index 33.
Relevant publications as corresponding author (ORCID: orcid.org/0000-0001-7166-6764):
Julio E. Sosa, A.B. Pereiro,* et al. "Process Evaluation of Fluorinated Ionic Liquids as F-Gases Absorbents". Environmental Science & Technology (IF=7.864) 2020, DOI: 10.1021/acs.est.0c05305. This paper reports a process evaluation of fluorinated ionic liquids (FILs) as potential fluorinated gases absorbents for the development of new separation processes.
N. S. M. Vieira, .B. Pereiro,* et al. "Tailor-made Fluorinated Ionic Liquids for Proteins Drug Delivery". Nanomaterials (Special Issue: Ionic Liquids as Task-Specific Materials, IF=4.324), 10, 2020, 1-16. This work offers a new perspective in the field of task-specific materials: ionic liquids for the development of novel delivery systems.
Paulo J. Castro, Andres E. Redondo, Julio E. Sosa, Malgorzata E. Zakrzewska, Ana V. M. Nunes, João M. M. Araújo, Ana B. Pereiro* "Absorption of Fluorinated Greenhouse Gases in Deep Eutectic Solvents" Industrial & Engineering Chemistry Research (IF=3.573, Special Issue: I&EC Research’s 2020 Class of Influential Researchers) 59, 2020, 13246−13259.
N.S.M. Vieira, A.B. Pereiro,* et al. "Aggregation and Phase Equilibria of Fluorinated Ionic Liquids". Journal of Molecular Liquids (IF=5.065) 285, 2019, 386-396. This paper contributes to design FILs with exceptional surfactant behaviour and surface properties in aqueous solutions.
Nicole S. M. Vieira, Stefan Stolte‖, João M. M. Araújo, Luís Paulo N. Rebelo, Ana B. Pereiro*, M. Markiewicz "Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids" ACS Sustainable Chemistry & Engineering (IF=7.632) 7, 2019, 3733-3741, This study provides greener and more sustainable fluorinated ionic liquids (FILs) for use in “green pharmacy”.
Nicole S. M. Vieira, Joana C. Bastos, Luís Paulo N. Rebelo, Ana Matias, João M. M. Araújo, Ana B. Pereiro* "Human cytotoxicity and octanol/water partition coefficients of fluorinated ionic liquids" Chemosphere (IF=5.778) 216, 2019, 576-586.
Joana C. Bastos, Sara F. Carvalho, Tom Welton, José N. Canongia Lopes, Luís Paulo N. Rebelo, Karina Shimizu, João M. M. Araújo and Ana B. Pereiro*. "Design of task-specific fluorinated ionic liquids: nanosegregation versus hydrogen-bonding ability in aqueous solutions". Chemical Communications (IF = 6.164) 54, 2018, 3524-3527, This work studies the control of the hydrogen bond acceptance capacity of FILs in aqueous solutions using fluorinated alkyl chains.
Márcia Alves, Nicole S. M. Vieira, Luís Paulo N. Rebelo, João M. M. Araújo, Ana B. Pereiro*, Margarida Archer. "Fluorinated Ionic Liquids for Protein Drug Delivery Systems: investigating their impact on the structure and function of lysozyme". International Journal of Pharmaceutics (IF = 3.862) 526, 2017, 309-320. This work constitutes a first step towards the biomedical application of FILs as nanocarriers. The encapsulation and stabilization/protection of a model therapeutic protein (lysozyme) using FILs were demonstrated for the first time.
Margarida L. Ferreira, María J. Pastoriza-Gallego, João M. M. Araújo, José N. Canongia Lopes, Luís Paulo N. Rebelo, Manuel M. Piñeiro, Karina Shimizu, Ana B. Pereiro*. "The Influence of Nanosegregation on the Phase Behavior of Fluorinated Ionic Liquids". Journal of Physical Chemistry C (IF =4.484) 121, 2017, 5415–5427. This paper demonstrates that fluorinated domains are an interesting structural feature that modifies and/or enhances the rich phase behaviour of FILs, thereby broadening the tuneability power of traditional ILs.
Ana M. Ferreira, Pedro D. O. Esteves, Isabel Boal-Palheiros, Ana B. Pereiro*, Luís Paulo N. Rebelo, Mara G. Freire. "Enhanced tunability afforded by aqueous biphasic systems formed by fluorinated ionic liquids and carbohydrates". Green Chemistry (IF = 9.125) 18, 2016, 1070-1079.
A.B. Pereiro*, J.M.M. Araújo, F.S. Teixeira, I.M. Marrucho, M.M. Piñeiro, L.P.N. Rebelo. "Aggregation Behavior and Total Miscibility of Fluorinated Ionic Liquids in Water". Langmuir (IF = 3.993), 31, 2015, 1283-1295. This paper provides for the first time the complete water solubility of non-toxic fluorinated ionic liquids (FILs), demonstrating improved surfactant behaviour with distinct self-assembled structures.
A.B. Pereiro*, M.J. Pastoriza-Gallego, K. Shimizu, I.M. Marrucho, J.N.C. Lopes, M.M. Piñeiro, L.P.N. Rebelo. "On the Formation of a New, Third, Nanostructured Domain in Ionic Liquids". Journal of Physical Chemistry B (IF=3.377) 117, 2013, 10826-10833. The formation of three nanosegregated domains (polar, non-polar and fluorinated) was demonstrated for the first time.
A.B. Pereiro*, J.M.M. Araújo, S. Martinho, F. Alves, S. Nunes, A. Matias, C.M.M. Duarte, L.P.N. Rebelo, I.M. Marrucho. "Fluorinated Ionic Liquids: Properties and Applications". ACS Sustainable Chemistry & Engineering (IF = 4.642) 1, 2013, 427-439.
A.B. Pereiro*, J.M.M. Araújo, F.S. Oliveira, C.E.S. Bernardes, J.M.S.S. Esperança, José N. Canongia Lopes, Isabel M. Marrucho, Luís P. N. Rebelo. "Inorganic Salts in Purely Ionic Liquid Media: The Development of High Ionicity Ionic Liquids (HIILs)". Chemical Communications (IF=6.378) 48, 2012, 3656-3658. Listed as nº 2 amongst The Best ILs Articles from RSC in the Chemical Communications, 2012, this work demonstrated that High Ionicity ILs can be developed from the fine-tuned addition of an inorganic salt to an IL.
A. B. Pereiro*, J. M. M. Araújo, J. M. S. S. Esperança, I. M. Marrucho, L. P. N. Rebelo. "Ionic Liquids in Separations of Azeotropic Systems – A Review". Journal of Chemical Thermodynamics (Special Issue on Thermodynamics of Sustainable Processes) (IF=2.297) 46, 2012, 2-28. This paper was awarded both Hot Paper and Highly Cited Paper (ESI 2014) status; this systematic analysis of the influence of IL structure on their azeotrope breaking capacity contributed to the establishment of guidelines for selecting the most suitable IL for the separation of azeotropic mixtures.