Maria Teresa Nunes Mangas Catarino

Assistant Professor
Biochemistry and Biophysics Section
(+351) 212948300

Research Interests

Modelling of the thermodynamic properties of proteins with multiple redox centres: homotropic and heterotropic cooperativities. Electron/proton coupling and energy transduction.
Kinetic modelling of electron transfer in proteins with multiple redox centres. Kinetic studies using stopped-flow techniques.
Structure and solution properties of haem-based sensors involved in signal transduction.
Binding of diatomic molecules (NO, CO, O2) to haem proteins.

Main Publications

1 – Turner, D.L., Salgueiro, C.A., Catarino, T., LeGall, J. and Xavier, A.V. (1996) NMR studies of cooperativity in the tetrahaem cytochrome c3 from Desulfovibrio vulgaris, Eur. J. Biochem. 241, 723-731.

2 – Louro, R.O., Catarino, T., Turner, D.L., Piçarra-Pereira, M.A., Pacheco, I., LeGall, J., and Xavier, A.V. (1998) Functional and mechanistic studies of cytochrome c3 from Desulfovibrio gigas: Thermodynamics of a “Proton-Thruster”, Biochemistry 37, 15808-15815.

3 – Catarino, T. and Turner, D.L. (2001) Thermodynamic control of electron transfer rates in multicentre redox proteins. ChemBioChem 2, 416-424.

4 – Correia, I.J., Paquete, C.M., Coelho, A., Almeida, C.C., Catarino, T., Louro, R.O., Frazão, C., Saraiva, L.M., Carrondo, M.A., Turner, D.L. and Xavier, A.V. (2004) Proton-assisted two-electron transfer in natural variants of tetrahaem cytochromes from Desulfomicrobium Sp. J. Biol. Chem. 279, 52227-52237.

5 – Paquete, C.M., Turner, D.L., Louro, R.O., Xavier, A.V. and Catarino, T., (2007) Thermodynamic and kinetic characterisation of individual haems in multicentre cytochromes c3. Biochim. Biophys. Acta, Bioenerg. 1767, 1169-1179.

6- Pokkuluri, P.R., Pessanha, M., Londer, Y.Y., Wood, S.J., Duke, N.E.C., Wilton, R., Catarino, T., Salgueiro, C.A. and Schiffer, M. (2008) Structures and solution properties of two novel periplasmic sensor domais with c-type heme from chemotaxis proteins, of Geobacter sulfurreducens: implications for signal transduction. J. Mol. Biol. 377, 1498-1517.

7- Catarino, T., Pessanha, M., De Candia, A.G., Gouveia, Z., Fernandes, A.P., Pokkuluri, P.R., Murgida, D., Marti, M.A., Todorovic, S. and Salgueiro, C.A. (2010) Probing the chemotaxis periplasmic sensor domains from Geobacter sulfurreducens by combined resonance Raman and molecular dynamic approaches: NO and CO sensing. J. Phys. Chem. B 114, 11251-11260.

8- Quintas, P.O., Catarino, T., Todorovic, S. and Turner, D.L. (2011) Highly selective ligand binding by Methylophilus methylotrophus cytochrome c” Biochemistry 50, 5624-5632.