My research interests lie in the field of synthetic organic chemistry. I am particularly interested in developing new synthetic methods and applying them to semi synthetic processes to the synthesis of target molecules possessing attractive biological activities.
Synthesis and properties of metabolites of organic compounds are also mater of interest.
“Synthesis and Cyclic Voltammetry Studies of 3,4-Methylenedioxymethamphetamine (MDMA) Human metabolites”, C. Macedo, P. S. Branco, L. M. Ferreira, A. M. Lobo, J. P. Capela, E. Fernandes., M. L. Bastos and F. Carvalho, J. Health Science, in press.
“Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('ecstasy') cytotoxicity”. H. Carmo, M. Brulport, M. Hermes, F. Oesch, R. Silva, L.M. Ferreira, P.S. Branco, D. de Boer, F. Remiao, F. Carvalho, M.R. Schon, N. Krebsfaenger, J. Doehmer, M.D. Bastos, and J.G. Hengstler, Pharmacogenet. Genomics, 16(11), 789-799, 2006.
“Neurotoxicity of ecstasy metabolites in rat cortical neurons, and influence of hyperthermia”, J.P. Capela, A. Meisel, A.R. Abreu, P.S. Branco, L.M. Ferreira, A.M. Lobo, F. Remiao, M.L. Bastos, and F. Carvalho, J. Pharmacol. Exp. Ther., 316(1), 53-61, 2006.
“New enantioselective method for hydration of alkenes using cyclodextrins as phase transfer catalyst”. A.R. Abreu, I. Costa, C. Rosa, L.M. Ferreira, A. Lourenco, and P.P. Santos, Tetrahedron, 61(50), 11986-11990, 2005.
“Reactions of 2-Acylthiazolium Salts with N-arylhydroxilamines”, L. M. Ferreira, A. C. Teixeira, A. M. Lobo, S. Prabhakar, Tetrahedron, 55, 3541-3552, 1999.