Faculdade

Eventos

Integrative Structural Biology tools for the study of protein-ligand interactions

 

The study of protein-ligand interactions is fundamental to the understanding of biological systems and is at the heart of the drug discovery process.

There are many biophysical methods available to study protein-ligand interactions that span from calorimetric techniques to spectroscopic and structural methods. Young researchers are usually familiar with one or more of these methods but often do not have the opportunity to address the problem from an integrated structural biology perspective.

In this course our main objective is to illustrate the added value of a structural biology approach to the study of protein-ligand interactions by combining four core methodologies: X-ray Crystallography, NMR, Carbohydrate Microarrays and ITC from a hands-on perspective, giving emphasis to their limitations and complementarities.

 

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