Faculdade

Departamento

Patrícia Mira Paes de Sousa Videira

Invited Researcher
Secção de Bioquímica e Biofísica
(+351) 212948300
(+351) 212948550

Research Interests

- Dynamic application of electrochemical methods to the study of the kinetics and energetics of metalloproteins and metalloenzymes: intra and intermolecular electron transfer processes; active site redox chemistry, catalytic mechanisms, inhibition, redox activation/inactivation, recognition of physiological partners;

- Development of novel electrode interfaces based on SAMs and nanomaterials that may mimic the physiological environment and thus enhance direct electron transfer between electrodes and redox proteins;

- Exploitation of redox assemblies and layer-by-layer films in order to enhance recognition and interaction of electron transfer partners, as well as catalytic performances. 

Main Publications

R Grazina, et al. (2011) Structural redox control in a 7Fe ferredoxin isolated from Desulfovibrio alaskensis, Bioelectrochem, doi:10.1016/j.bioelechem.2011.04.005.

PM Paes de Sousa, et al. (2011) Analysis of the activation mechanism of Pseudomonas stutzeri cytochrome c peroxidase through an electron transfer chain, J Biol Inorg Chem, 16, 881–888.

PM Paes de Sousa, et al. (2011) Artefacts induced on c-type haem proteins by electrode surfaces, J Biol Inorg Chem, 16, 209–215.

S Dell’Acqua, et al. (2010) A new CuZ active form in the catalytic reduction of N2O by nitrous oxide reductase from Pseudomonas nautica, J Biol Inorg Chem, 15, 967–976.

PM Paes de Sousa, et al. (2008) Benefits of membrane electrodes in the electrochemistry of metalloproteins: mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by horse cytochrome c – a case study, J Biol Inorg Chem, 13, 779-787.

PM Paes de Sousa, et al. (2007) Mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by Paracoccus pantotrophus pseudoazurin – kinetics of intermolecular electron transfer, J Biol Inorg Chem, 12, 691-698.

MM Correia dos Santos, et al. (2004) Direct electrochemistry of the Desulfovibrio gigas aldehyde oxidoreductase, Eur J Biochem, 271, 1329-1338.