Olga Yu. Gavel
Investigador Pós-Doc
Secção de Bioquímica e Biofísica
(+351) 212948300 (+351) 212948550
olga.gavel@dq.fct.unl.pt
Secção de Bioquímica e Biofísica
(+351) 212948300 (+351) 212948550
olga.gavel@dq.fct.unl.pt
Interesses Científicos
O domínio de especialização é bioquímica, biofísica e espectroscopia de metaloenzimas. Interesse especial focada em:
- O metaloproteínas de bactérias redutoras de sulfato envolvidas na via de energia ou processos de oxidação-redução.
- Estabilidade de proteínas e peroxidases.
Publicações Representativas
"Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria" Mukhopadhyay A, Kladova AV, Bursakov SA, Gavel OY, Calvete JJ, Shnyrov VL, Moura I, Moura JJ, Romão MJ, Trincão J., J. Biol. Inorg. Chem., 51-61, 2011
"Thermodynamic characterization of the palm tree Roystonea regia peroxidase stability" Zamorano LS, Pina DG, Arellano JB, Bursakov SA, Zhadan AP, Calvete JJ, Sanz L, Nielsen PR, Villar E, Gavel O, Roig MG, Watanabe L, Polikarpov I, Shnyrov VL. Biochimie 90, 1737-1749, 2008
"A new type of metal-binding site in cobalt- and zinc-containing adenylate kinases isolated from sulfate-reducers Desulfovibrio gigas and Desulfovibrio desulfuricans ATCC 27774" Gavel O.Yu., S.A.Bursakov, G.DiRocco, J.Trincão, I.J.Pickering, G.N.George, J.J.Calvete, V.L.Shnyrov, C.D.Brondino, A.S.Pereira, J.Lampreia, P.Tavares, J.J.G.Moura and I.Moura
J Inorg Biochem. 102, 1380-1395, 2008.
“Structural stability of adenylate kinase from the sulfate-reducing bacteria Desulfovibrio gigas” O.Yu.Gavel, S.A.Bursakov, D.G.Pina, G.G.Zhadan, J.J.G.Moura, I.Moura, V.L.Shnyrov Biophys Chem., 110(1-2), 83-92, 2004.
“Antagonists Mo and Cu in a heterometallic cluster present on a novel protein (orange protein) isolated from Desulfovibrio gigas” S.A.Bursakov, O.Yu.Gavel, G.Di Rocco, J.Lampreia, J.Calvete, A.S.Pereira, J.J.G.Moura, I.Moura J Inorg Biochem., 98(5), 833-840, 2004.
“Sulfate activation (biological)” J.J.G.Moura, S.A.Bursakov, O.Yu.Gavel, I.Moura. Encyclopedia of catalysis. John Wiley & Sons. Published on Internet: http://www.mrw.interscience.wiley.com, 2002.
“Purification and characterization of a tungsten-containing formate dehydrogenase from Desulfovibrio gigas” M.J.Almendra, C.D.Brondino, O.Yu.Gavel, A.S.Pereira, P.Tavares, S.A.Bursakov, R.Duarte, J.Caldeira, J.J.G.Moura, and I.Moura, Biochemistry, 38(49), 16366-16372, 1999.
“ATP sulfurylase from sulfate-reducing bacteria of the genus Desulfovibrio. A novel metalloprotein containing cobalt and zinc”. O.Yu.Gavel, S.A.Bursakov, J.J.Calvete, G.N.George, J.J.G.Moura, I.Moura, Biochemistry, 37(46), 16225-16232, 1998.