Peak tailing

What you expect

What you got

Disease Medicine
Active sites within the column Test with standard test mixture. If OK add competing base or acid modifier
Wrong pH Correct
Wrong column Change
Void volume at inlet May need repacking
Wrong sample solvent Dissolve sample in mobile phase
Back enter the troubleshooter parlor
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Disease	Medicine
Active sites within the column	Test with standard test mixture. If OK add competing base or acid modifier
Wrong pH	Correct
Wrong column	Change
Void volume at inlet	May need repacking
Wrong sample solvent	Dissolve sample in mobile phase

Send comments to:
Prof. Dr. H.J. Chaves das Neves
Department of Chemistry
Faculdade de Ciências e Tecnologia
Universidade Nova de Lisboa
2825 Monte da Caparica
Portugal

hcn@dq.fct.unl.pt